順天堂大学医学部附属順天堂越谷病院
  医学部附属病院 病院マップ 学校法人順天堂 ホーム
順天堂越谷病院 脳神経内科
スタッフの活動
従来の研究活動の紹介(頼高朝子医師)
パーキンソン病における脂質過酸化などのフリーラジカルに関する研究、遺伝子研究を手がけた。治療に関する多施設共同二重盲検試験やパーキンソン病の縦断的観察研究を行っている。
研究業績
英文原著
  1. Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A. 93:2696-2701, 1996,
  2. Yoritaka A, Hattori N, Mori H, Kato K, Mizuno Y. An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease. J Neurol Sci.148:181-186,1997,
  3. Shimoda-Matsubayashi S, Hattori T, Matsumine H, Shinohara A, Yoritaka A, Mori H, Kondo T, Chiba M, Mizuno Y. Mn SOD activity and protein in a patient with chromosome 6-linked autosomal recessive parkinsonism in comparison with Parkinson's disease and control. Neurology 49:1257-1262, 1997,
  4. Yoritaka A, Hattori N, Yoshino H, Mizuno Y. Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication. J Neural Transm 104:1313-1317, 1997,
  5. Matsumine H, Yamamura Y, Hattori N, Kobayashi T, Kitada T, Yoritaka A, Mizuno Y. A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2). Genomics 49:143-146, 1998,
  6. Hattori N, Matsumine H, Asakawa S, Kitada T, Yoshino H, ElibolB, Brookes AJ, Yamamura Y, Kobayashi T, Wang M, Yoritaka A, Minoshima S, Shimizu N, and Mizuno Y. Point Mutations (Thr240Arg and Ala311Stop) in the Parkin Gene. Biochem Biophys Res Commun 249: 754-758,1998,
  7. Hattori N, Kitada T, Matsumine H, Asakawa S, Yamamura Y, Yoshino H, Kobayashi T, Yokochi M, Wang M, Yoritaka A, Kondo T, Kuzuhara S, Nakamura S, Shimizu N, Mizuno Y. Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the Parkin gene in affected individuals. Ann Neurol 44:935-941, 1998,
  8. Miwa H, Yoritaka A, Mizuno Y. Hemifacial spasm in Parkinson's disease. Mov Disord 14:358-35, 1999,
  9. Yoritaka A, Nakagawa-Hattori Y, Hattori N, Kitahara A, Mizuno Y. A large Japanese family with Machado-Joseph disease: clinical and genetic analysis. Acta Neurol Scand. 99:241-244, 1999,
  10. Yoritaka A, Tsukamoto T, Ohta K, Kishida S. Facial myokymia associated with an isolated lesion of the facial nucleus. Acta Neurol Scand. 104:182-184, 2001,
  11. Yoritaka A, Arai N, Ohta K, Tsukamoto K, Kishida S. Single photon emission computed tomography of an acute focal demyelinating disease mimicking a brain tumor. Eur Neurol 48:222-223, 2002,
  12. Yoritaka A, Sakai M, Ohta K, Kishida S. A case of Crow-Fukase syndrome showing improvement following excision and irradiation of bone lesions. Clinical Neurology 44:369-371,2004,
  13. Yoritaka A, Yamada R, Ohta K, Kishida S. Successful treatment by fluconazole in a case of candida brain abscesses with renal and hepatic failure. Neuroinfection 2004; 9: 86-88
  14. Sanaka M, Kishida S, Yoritaka A, Sasamura Y, Yamamoto T, Kuyama Y. Acute upper airway obstruction induced by an indwelling long intestinal tube: attention to the nasogastric tube syndrome. J Clin Gastroenterol 38:913, 2004,
  15. Arai N, Kishida S, Yoritaka A, Ohta K. Clinical investigation of the 8 cases with AIDS (acquired immunodeficiency syndrome)-associated progressive multifocal leukoencephalopathy (PML). Clinical Neurology 45:89-95, 2005,
  16. Ohta K, Mori M, Yoritaka A, Okamoto K, Kishida S. Delayed ischemic stroke associated with methamphetamine use. J Emerg Med 28:165-7, 2005,
  17. Yoritaka A, Ohta K, Kishida S. Herpetic lumbosacral radiculoneuropathy in patients with patients with human immunodeficiency virus infection. Eur Neurol 53:179-181, 2005,
  18. Yoritaka A, Ohta K, Akiyama H, Kishida S. Limbic encephalitis probably due to human herpes virus 6 after stem cell transplantation: A report of 3 cases. Neuroinfection 10: 88-93, 2005
  19. Yoritaka A, Hishima T, Akagi K, Kishida S. Successful steroid treatment of acquired idiopathic partial hypohydrosis. J Dermatology 33:265-267, 2006,
  20. Yoritaka A, Ohta K, Kishida S. Prevalence of neurological complications in Japanese patients with AIDS after the introduction of HAART. Clinical Neurology 47:491-496, 2007,
  21. Iizuka Y, YamashiroY, Suzuki M, Oizumi H, Yoritaka A, Tanaka S. Possible role local hypoxia in the de novo formation of dural and osteodural arteriovenous fistulas after encephalitis. Neuroradiol Journal 21:698-703, 2008,
  22. Tsutsumi S, Yasumoto Y, Ito M, Oishi H, Arai H, Yoritaka A. Atypical dural arteriovenous fistula associated with meningitis. Neurol Med Chir 48: 68-71, 2008,
  23. Yoritaka A, Ohizumi H, Tanaka S, Hattori N.  Parkinson's Disease with and without REM Sleep Behaviour Disorder: Are There Any Clinical Differences? Eur Neurol 61:164-170, 2009,
  24. Hattori N, Wanga M, Taka H, Fujimura T, Yoritaka A, Kubo S, Mochizuki H. Toxic effects of dopamine metabolism in Parkinson's disease. Parkinsonism Relat Disord;15 Suppl 1:S35-8, 2009,
  25. Kawanabe T, Yoritaka A, Shimura H, Oizumi H, Tanaka S. Hattori N. Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. Progress in Neuropsychopharmacology & Biological Psychiatry;34: 284-287, 2010,
  26. Hatano T, Shimada Y, Kono A, Kubi SI, Yokoyama K, Yoritaka A, Nakahara T, Takanashi Y, Hattori N. Atypical Miller Fisher syndrome associated with glutamate receptor antibodies. BMJ Case reports 2011,
  27. Yoritaka A, Shimo Y, Shimo Y, Inoue Y, Yoshino H, and Hattori N. Nonmotor Symptoms in Patients with PARK2 Mutations. Parkinson disease.; 13: 473640, 2011,
  28. Shimada Y, Yoritaka A, Tanaka Y, Miyamoto N, Ueno Y, Hattori N, Takao U. Cerebral infarction in a young man using high-dose anabolic steroids. J Stroke Cerebrovasc Dis 21:906, 2012,
  29. Homma H, Yoritaka A, Hattori N, Kobayakawa T, Ikeda K. Clinical application of a card-type odor identification test to olfactory assessment in Parkinson's disease. Auris Nasus Larynx 40:173-6, 2013,
  30. Yoritaka A, Shimo Y, Takanashi M, Fukae J, Hatano T, akahara T, Miyamato N, Urabe T Mori H, Hattori N. Motor and non-motor symptoms of 1453 patients with Parkinson’s disease: Prevalence and risks. Parkinsonism Relat Disord 19: 725-731, 2013,
  31. Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N. Pilot study of H2 therapy in Parkinson’s Disease: A Randomized Double-blind Placebo-controlled Trial. Mov Disord 28:836-839, 2013,
  32. Yoritaka A, Shimo Y, Takanashi M, Fukae J, Hatano T, Nakahara T, Miyamato N, Urabe T, Hattori N. Motor and Non-Motor Symptoms of 1453 Patients with Parkinson’s Disease: Any Relationship with the Cumulative Doses of Anti-Parkinsonian Medications? J Neurological Disorders & Stroke. 2 (2) 2014,
  33. Hatano T, Hattori N, Kawanabe T, Terayama Y, Suzuki N, Iwasaki Y, Fujioka T; Yokukansan Parkinson’s Disease Study Group. An exploratory study of the efficacy and safety of yokukansan for neuropsychiatric symptoms in patients with Parkinson's disease. J Neural Transm 121:275-81, 2014,
  34. Fukae J, Ishikawa K, Hatano T, Yoritaka A, Takanashi M, Shimo Y, Tsugawa J, Tsuboi Y, Hattori N. Serum uric acid concentration is linked to wearing-off fluctuation in Japanese Parkinson's disease patients. J Parkinsons Dis 4:499-505, 2014,
  35. Tsunemi Y, Takano T, Sato N, Yoritaka A, Ushimi T, Tamura N. Two cases of MERS associated with Legionnaires' Disease. Japanese Journal of Clinical Radiology 59: 202-209, 2014,
  36. Fusegi K, Yoritaka A, Hattori N, Mori H. Automatic behavior in Parkinson's disease. Parkinsonism Relat Disord 21:84-5, 2015,
  37. Fukae J, Higuchi MA, Yanamoto S, Fukuhara K, Tsugawa J, Ouma S, Hatano T, Yoritaka A, Okuma Y, Kashihara K, Hattori N, Tsuboi Y. Utility of the Japanese version of the 9-item Wearing-off Questionnaire. Clin Neurol Neurosurg 134:110-5, 2015,
  38. Yoritaka A, Kawajiri S, Yamamoto Y, Nakahara T, Ando M, Hashimoto K, Nagase M, Saito Y, Hattori N. Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease. Parkinsonism Relat Disord 21:911-6, 2015,
  39. Yoritaka A, Fukae J, Hatano T, Hattori N. The Direct Cost of Parkinson Disease at Juntendo Medical University Hospital, Japan. Internal Medicine; 55:113-9, 2016,
  40. Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Hattori N. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurol 16:66, 2016
  41. Yoritaka A, Mori H, Hattori N. Treatment of Mild Camptocormia with Selegiline in Patients with Parkinson's Disease. Eur Neurol. Jun 29:35-39, 2016,
  42. Ouma S, Fukae J, Fujioka S, Yamamoto S, Hatano T, Yoritaka A, Okuma Y, Kashihara KI, Hattori N, Tsuboi Y. The Risk Factors for the Wearing-off Phenomenon in Parkinson's Disease in Japan: A Cross-sectional, Multicenter Study. Intern Med 56:1961-1966, 2017
  43. Yoritaka A, Hattori N. Differences between responders and non-responders in Parkinson’s disease. Advance in Parkinson’s disease 2017; DOI:10.4236 ⁄apd.2017.62005
  44. Havashid, A, Li Y, Yoshino H, Nakahara T, Yoritaka A, Nagara Y, Sakiyama Y, Kusaka H, Takiyama Y, Morimoto N, Uchino A, Fujimoto T, Sekijima Y, Tomimoto, H, Tsurut, K, Hattori, Y, Kashihara K, Funayama, M, Nishioka K, Hattori, N. Pink1 heterozygous mutations in familial Parkinson's disease: J Neurological Sci 381: 161-162, 2017
  45. Yoritaka A, Abe T, Ohtsuka C, Maeda T, Hirayama M, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Hattor N: A randomized double-blind, placebo-controlled multi-center trial of molecular hydrogen water for Parkinson's disease J Neurological Sci 381: 161-162, 2017
  46. Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease. Mov Disord 2018 ;33 :1505-1507.
  47. Hirayama M, Ito M, Minato T, Yoritaka A, LeBaron TW, Ohno K. Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease. Med Gas Res. 2019 9;8: 144-149.
和文原著
  1. 頼高朝子,杉浦和朗,平松まき,馬場元毅.定位的吸引排膿術が奏効した視床部脳膿瘍の1例.脳と神経42:749-53, 1990.
  2. 頼高朝子,平松まき,鵜飼宏,沢浦美奈子.右利き交叉性失語症に伴った再帰性発話.神経内科 34:397-401,1991
  3. 頼高朝子,平松まき,鵜飼宏,沢浦美奈子.Clonazepamが奏効した顎関節強直症.神経内科; 35:430-432,1991
  4. 頼高朝子,小河原一成,吉野英夫,今井壽正,水野美邦.外眼筋炎とTolosa-Hunt症候群に関する臨床的並びに神経放射線学的検討.臨床神経学 32:593-599, 1992
  5. 小島淳,頼高朝子,池辺慎一郎,中島八十一,水野美邦.視覚失認を呈した老年痴呆の1例:視覚情報処理過程からみた障害部位の推定.脳と神経; 48:31-37,1996
  6. 頼高朝子,服部達也,服部優子,森秀生,松岡周二,白井俊一,近藤智善,水野美邦80歳発症,歩行障害を主訴とした85歳女性.脳と神経49:379-389, 1997.
  7. 中村利生,頼高朝子,角野禎子,鈴木宏昌,森秀生,須田耕一,田久保秀樹,水野美邦.歩行障害,眼球運動障害を主症状とした70歳男性.脳と神経; 49:93-100,1997
  8. 太田恵子,頼高朝子,岸田修二. ブルセラ症. 神経内科 53:304-305, 2000
  9. 頼高朝子,塚本忠,大田恵子,岸田修二.肥厚性硬膜炎の臨床的検討.脳と神経54: 235-240, 2002.
  10. 大田恵子,頼高朝子,坂巻壽,岸田修二,駒込病院骨髄移植グループ.骨髄移植の経過中発症した免疫抑制剤による脳症の検討.脳と神経 56:395-401, 2004.
  11. 木原武士, 頼高朝子, 大栗優一, 杉山奈未, 宮澤仁朗. 簡便な認知機能テストとCDTを組み合わせたスクリーニングツールの開発 Progress in Medicine 2:369-375,2013
  12. 常見安史,頼高朝子,平松まき,牛見尚史,田村直,高野智子,佐藤信英. 同時期に経験したレジオネラ感染によるMERSの2例 臨床放射線59:201-209,2014
  13. 頼高朝子 パーキンソン病における認知機能障害 cognitive impairment in Parkinson’s disease 老年期認知症研究会誌20:60-62,2017
和文著書
  1. 酸化的ストレス. パーキンソン病ハンドブック.頼高朝子, 望月秀樹, 水野美邦編,中外医学社,東京,259-268, 2001
  2. 脳炎、感染症クリニカルガイダンス.頼高朝子、岸田修二,後藤元、斧康雄編,ヴァンメデイカル,東京,160‐162,2004
  3. 脳膿瘍 感染症クリニカルガイダンス.頼高朝子、岸田修二,後藤元、斧康雄編,ヴァンメデイカル,東京,163‐165,2004
  4. 酸化的ストレス. パーキンソン病ハンドブック, 頼高朝子, 望月秀樹.水野美邦編, 中外医学社, 東京,294-305,2007.
  5. 在宅医学の対象別諸課題C 内科的疾患進行期の医学的管理2 神経難病 2)その他の神経難病.在宅医学.頼高朝子,田中茂樹,日本在宅医学会テキスト編集委員会編, メディカルビュー社,東京,355-358,2008.
  6. パーキンソン病治療薬. 新薬展望. 頼高朝子,服部信孝, 政田幹夫、佐藤博、佐々木均編, 医薬ジャーナル, 大阪,355-358,2009.
  7. 感染性疾患. 神経内科ハンドブック第4版. 頼高朝子, 望月秀樹, 水野美邦編,医学書院,東京,699-770,2009
  8. パーキンソン病における睡眠障害への対応は?いきなり名医!パーキンソン病 Q&A. 頼高朝子、服部信孝編,日本医事新報社,東京,118-121,2009
  9. パーキンソン病診療役立ちコラム その1 パーキンソン病の情報とその活用.あなたも名医!ここを押さえる!パーキンソン病診療. 頼高朝子. 服部信孝編,日本医事新報社,東京,30,2012
  10. 患者さんは医師に何を望んでいるのか?あなたも名医!ここを押さえる!パーキンソン病診療. 頼高朝子 服部信孝編, 日本医事新報社,東京,157-161,2012
  11. 認知症に有効な漢方薬について教えてください.どのような症状に対して使用するのか,また使用する際の注意点はどういったものがありますか?認知症診療Q&A92. 頼高朝子、森秀生,中島健二,和田健二編,中外医学社,東京,218-221,2012
  12. 順天堂大学が教えるパーキンソン病の自宅療法.頼高朝子,服部信孝編,主婦の友インフォス情報社,東京,112-117,2014
  13. パーキンソン病・アルツハイマー型認知症 コエンザイムQ10の基礎と応用. 頼高朝子、服部信孝,コエンザイムQ協会編,丸善プラネット, 97-104,2015
  14. 訪問診療の診かた,考え方 6.パーキンソン病.頼高朝子,大久保光夫編,中外医学社 東京,121-127, 2017
  15. パーキンソン病(第2版)II.病因 その他の因子 酸化ストレス.頼高朝子,服部信孝編,日本臨床増刊号 日本臨床社, 東京,167-173,2018


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